Renew Life Ultimate Flora Critical Care 50 Billion Probiotic Strains

Compilation of Published Research Abstracts

Compiled: January 2010

Renew Life Ultimate Flora Critical Care 50 Billion™ is developed with 10 specific probiotics strains, each independently studied for efficacy and effectiveness in supporting digestive and immune health.

Bifidobacterium bifidum

B. bifidum is a resident strain of bacteria native to the human digestive tract that resides mostly in the bowel. It has been shown to lower the incidence of allergies and digestive complaints. B. bifidum specifically reduces in numbers with age, with its populations dipping prominently after age 50. B. bifidum has been shown to boost the immune system, it’s been shown to increase IgG, IgM and IgA. It has also been shown to help reduce diarrhea and rotavirus shedding in hospitalized infants.

• Schell MA, Karmirantzou M, Snel B, Vilanova D, Berger B, Pessi G, Zwahlen MC, Desiere F, Bork P, Delley M, Pridmore RD, Arigoni F (October 2002). "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract.". Proceedings of the National Academy of Science U S A.: 14422-7. PMID 12381787.
• Björkstén B, Sepp E, Julge K, Voor T, Mikelsaar M (October 2001). "Allergy development and the intestinal microflora during the first year of life". The Journal of Allergy and Clinical Immunology 108 (4): 516–20. doi:10.1067/mai.2001.118130. PMID 11590374.
• Guarner F, Malagelada JR (February 2003). "Gut flora in health and disease". Lancet 361 (9356): 512–9. doi:10.1016/S0140-6736(03)12489-0. PMID 12583961.
• Ko Ej, Goh JS, Lee BJ, Choi SH, Kim PH (September 1999) “Bifidobacterium bifidum exhibits a lipopolysaccharide-like mitogenic activity for murine B lymphocytes.” Journal of Dairy Science 82 (9): 1869-76. PMID: 10509245
• Park JH, Um JI, Lee BJ, Goh JS, Park SY, Kim WS, Kim PH. “Encapsulated Bifidobacterium bifidum potentiates intestinal IgA production.” Cell Immunol. 2002 Sep;219(1):22-7

Bifidobacterium breve

Another resident strain of bacteria, known to inhabit the bowel, especially in breastfed infants. B breve can colonize the immature bowel very effectively and is associated with fewer abnormal abdominal signs and better weight gain in VLBW infants (very low birth weight). B. Breve has been shown to repress the growth of ulcer-inducing bacteria. B. Breve has also been shown as being beneficial for those with Short Bowel Syndrome and can help with preventing the adherence of H. pylori in the stomach and small intestine.

• Early administration of Bifidobacterium breve to preterm infants: randomized controlled trial. H. Kitajima, Y. Sumida, R. Tanaka, N. Yuki, H. Takayama, and M. Fujimura Arch Dis Child Fetal Neonatal Ed. 1997 March; 76(2): F101–F107. PMCID: PMC1720633.

Bifidobacterium longum

Another beneficial resident strain of bacteria which creates beneficial acids which create an acidic pH in the lower gut, reducing negative pathogens naturally. B. Longum is one of most important inhabitants in the human body. This bacterium is very helpful because it maintains a normal digestive tract, inhibits the growth of harmful bacteria, and also boosts the immune system. It has been seen that Bifidobacteria may have some association with the prevention of several allergic diseases as well as diarrhea prevention in antibiotic treated patients, cholesterol reduction, alleviation of lactose intolerance symptoms and immune stimulation. B. Longum is also one of the first types of bacteria humans produce and is found in high amounts in the intestinal tracts of healthy breastfed infants.

• Reinert, Birgit. "Friendly tenants in the human gut: The genome of B. longum". 2002. Genome News Network.
• http://genome.jgi-psf.org/biflo/biflo.home.html

Lactobacillus acidophilus

Another beneficial resident strain of bacteria which creates beneficial acids which create an acidic pH in the lower gut, reducing negative pathogens naturally. L. acidophilus is part of the normal vaginal flora. The acid produced by L. acidophilus in the vagina may help to control the growth of Candida, thus helping to prevent vaginal yeast infections. The same beneficial effect has been observed in cases of oral or gastrointestinal candida overgrowth. L. acidophilus has also been shown to be helpful with indigestion, diarrhea and constipation.

• Ljungh A, Wadström T (2006). "Lactic acid bacteria as probiotics". Curr Issues Intest Microbiol 7 (2): 73–89. PMID 16875422.
• Forsum U, Holst E, Larsson P, Vasquez A, Jakobsson T, Mattsby-Baltzer I (2005). "Bacterial vaginosis--a microbiological and immunological enigma". APMIS

Lactobacillus plantarum

L. Plantarum is commonly found in many fermented food products and is also present in saliva (from which it was first isolated). It has most notably been studied to help patients with IBS and may be helpful for Chron’s disease too.

• European Journal of Gastroenterology & Hepatology: October 2001 - Volume 13 - Issue 10 - pp 1143-1147. A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome. Niedzielin, Krzysztof; Kordecki, Hubert; Birkenfeld, Boz ena.
• Fedorak, Dr. Richard, Digestive Disease Week 2003. http://www.crohns.net/Miva/education/articles/fedorak_DDW.shtml Fedorak

Lactobacillus bulgaricus

Lactobacillus bulgaricus is a lactic acid producing bacteria found in yogurt that is helpful for lactose intolerance, diarrhea and immunity. It also helps to promote the growth of other beneficial bacteria and as a result helps to maintain a healthy immune system. It may also help the body to metabolize lipids and maintain healthy cholesterol levels. Because L. bulgaricus has antibiotic properties, it can help prevent infections and prevent the proliferation of pathogenic microorganisms in the gut.

Lactobacillus casei

Found in the human intestinal tract and mouth, L. Casei is known to improve digestion and reduce lactose intolerance and constipation. It is theorized that L. Casei has a protective effect on the gut and helps to reduce intestinal permeability or “leaky gut” and that’s why it has health benefits to humans.

• Res Microbiol. 2005 Mar;156(2):256-62. Epub 2004 Dec 15. Lactobacillus casei DN-114 001 inhibits the increase in paracellular permeability of enteropathogenic Escherichia coli-infected T84 cells.Parassol N, Freitas M, Thoreux K, Dalmasso G, Bourdet-Sicard R, Rampal P.

Lactococcus lactis

L. Lactis used in the production of buttermilk and cheese because it produces lactic acid. It is helpful in incidences of Listeria or food poisoning. It has also been shown to be helpful for Colitis in animal studies.

• Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10. Lothar Steidler, Wolfgang Hans, Lieven Schotte, Sabine Neirynck, Florian Obermeier, Werner Falk, Walter Fiers, Erik Remaut. Department of Molecular Biology, Ghent University and Flanders Interuniversity Institute for Biotechnology, K. L. Ledeganckstraat 35, 9000 Gent, Belgium. Department of Internal Medicine I, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany.

Lactobacillus rhamnosus

Studies have shown that L. rhamnosus “can reduce colonization of the vagina by potential pathogenic bacteria and yeast” and can help with preventing the adherence of H. pylori in the stomach and small intestine. L. rhamnosus has also been shown to help strengthen the intestinal lining, helping with Crohn’s disease and protecting immunity.

• Ann Nutr Metab. 1996;40(3):137-45. Promotion of IgA immune response in patients with Crohn's disease by oral bacteriotherapy with Lactobacillus GG. Malin M, Suomalainen H, Saxelin M, Isolauri E. Department of Pediatrics, Tampere University Hospital, Finland.

Lactobacillus salivarius

L. salivarius is known to help with preventing the adherence of H. pylori in the stomach and small intestine. Some research suggests that it is also helpful for periodontal and gum issues.

• Strain-specific inhibition of Helicobacter pylori by Lactobacillus salivarius and other lactobacilli. Kieran A. Ryan, Paul Daly, Yin Li, Carmel Hooton and Paul W. O'Toole. 1 Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; 2 Department of Microbiology, University College Cork, Cork, Ireland; 3 Department of Microbiology, Cork University Hospital, Cork, Ireland.
• Effects of orally administered Lactobacillus salivarius WB21 supplement on periodontal clinical parameters and microflora. Gen Mayanagi, Seigo Nakaya8, Keiko Yamaki, Yasuhiro Ito, Maiko Minamibuchi, Moto Kimura, Haruhisa Hirata and Hidetoshi Shimauchi Division of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, 980-8575(8) Sagami Research Laboratories, Wakamoto Pharmaceutical Co., Ltd., Kanagawa 258-0018, Japan.