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Vitamin D and IBD

Inflammatory bowel disease, or IBD, is characterized by inflammation of the intestines, and is most notably represented as Crohn’s disease, which usually affects the small intestine, but may affect other areas of the digestive tract, and ulcerative colitis, which usually affects the large intestine, or colon.

Two recent studies, presented at the American College of Gastroenterology’s 76th Annual Scientific Meeting, discovered a connection between IBD and vitamin D status, or with latitude of geographic location at age 30. Latitude has been found to be strongly correlated with vitamin D status, because vitamin D is most commonly obtained through UV sun exposure. Those people living at higher latitudes are more likely to have insufficient vitamin D status; thus, the vitamin D connection to IBD.

In one study, it was found that people who lived in northern US latitudes at age 30 were more likely to later develop IBD. The researchers stated, “This differential risk may be explained by differences in UV light exposure, vitamin D status, or pollution.” The risk of developing Crohn’s disease was 50 percent lower in those people living in southern latitudes at age 30, and for ulcerative colitis, it was 35 percent lower.

In the second study, vitamin D3 supplementation was given to Crohn’s patients with low blood levels of vitamin D. The low-dose group received 1,000 IU daily, and the high-dose group received 10,000 IU daily. After 26 weeks of supplementation, there were differences in vitamin D levels, but more importantly, there was a significant improvement of disease symptoms in the high-dose compared to the low-dose group.

So many conditions are affected by insufficient vitamin D levels. If you do not know your vitamin D level, get it checked, even if you live in the south. Most integrative doctors recommend a vitamin D level of at least 50 ng/dL.

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Omega-3s for Anxiety

Anxiety, or worry, is experienced by just about everyone at some point. Some people have anxiety disorders, which are more serious conditions, but it’s safe to say that most people experience at least occasional anxiety. That’s why a new study on omega-3s found in fish oil is so exciting. It’s the first study to look at the effects of fish oil on anxiety in a healthy population—meaning, in people who don’t already have an anxiety disorder. It’s already known that fish oil can be helpful for those people. But what about people who only experience anxiety here and there?

The researchers took a group of medical students and gave them omega-3 supplements for three months. The supplements contained 2,085 mg of EPA and 348 mg of DHA. Another group got a placebo. After three months, the group taking the fish oil showed a 20 percent reduction in anxiety scores and a 14 percent reduction in the production of the inflammatory marker interleukin-6 (IL-6) over the placebo group.

IL-6 is an inflammatory cytokine. Depression and anxiety are both known to involve the production of inflammatory cytokines. This is one of the gut-brain connections, actually, since the inflammation can originate in the gut. Omega-3s were able to reduce these inflammatory compounds, highlighting just one way they may be helping mood disorders like depression and anxiety.

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